abstract

• In this work, Surface-enhanced Raman Scattering had been applied to detect L-Asparagine. The presence of this amino acid in tissues and fluids helps to the prevalence of acute lymphoblastic leukemia cells and promotes the proliferation of metastasis for some other malignant tumors; depletion of L-Asparagine is up to date the best treatment for leukemia and could improve the prognosis for other cancers. We have carried out the preparation and characterization of two types of metallic surfaces, one with nanoparticles and the other one with nanostructures; we obtained and compared the SERS spectra and enhancement factors between them to emphasize the advantages in each one. The principal aim of this work is to establish the basis for a new reliable biosensor capable of being used in clinical applications. © 2021 SPIE. All rights reserved.

authors

• González Contreras Francisco Javier
• Mendez J.

publication date

• 2021-01-01

funding provided via

• 278291; P105; Consejo Nacional de Ciencia y Tecnología, CONACYT: 293704  Grant

published in

• Progress in Biomedical Optics and Imaging - Proceedings of SPIE  Proceedings

keywords

• L-Asparagine; Raman Scattering; SERS Amino acids; Diagnosis; Diseases; Medical applications; Raman scattering; Raman spectroscopy; Acute lymphoblastic leukemia; Clinical application; Enhancement factor; L asparagines; Malignant tumors; Metallic surface; SERS spectrum; Surface enhanced Raman Scattering (SERS); Surface scattering

Digital Object Identifier (DOI)

• 10.1117/12.2577931

PubMed ID

start page

end page

volume

• 11657

issue