Deciphering the long non-coding rnas and micrornas coregulation networks in ovarian cancer development: An overview
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Non-coding RNAs are emergent elements from the genome, which do not encode for proteins but have relevant cellular functions impacting almost all the physiological processes occurring in eukaryotic cells. In particular, microRNAs and long non-coding RNAs (lncRNAs) are a new class of small RNAs transcribed from the genome, which modulate the expression of specific genes at transcriptional and posttranscriptional levels, thus adding a new regulatory layer in the flux of genetic information. In cancer cells, the miRNAs and lncRNAs interactions with its target genes and functional pathways are deregulated as a consequence of epigenetic and genetic alterations occurring during tumorigenesis. In this review, we summarize the actual knowledge on the interplay of lncRNAs with its cognate miRNAs and mRNAs pairs, which interact in coregulatory networks with a particular emphasis on the mechanisms underlying its oncogenic behavior in ovarian cancer. Specifically, we reviewed here the evidences unraveling the relevant roles of lncRNAs/miRNAs pairs in altered regulation of cell migration, angiogenesis, therapy resistance, and Warburg effect. Finally, we also discussed its potential clinical implications in ovarian cancer and related endocrine disease therapies. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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Co-regulation networks; Gene expression; Long non-coding RNAs; MicroRNAs; Ovarian cancer anisomycin; baculoviral IAP repeat containing protein 5; cyclin B1; fluoropyrimidine; immunoglobulin kappa chain; long untranslated RNA; microRNA 21; microRNA 210; microRNA 34a; mitochondrial DNA; paclitaxel; phosphoinositide dependent protein kinase 1; protein p53; RNA binding protein; RNA polymerase II; small untranslated RNA; stromal cell derived factor 1; thymidylate synthase; transcription factor EZH2; transcription factor Sp1; long untranslated RNA; microRNA; RNA; aerobic glycolysis; animal cell; antineoplastic activity; cancer prognosis; carcinogenesis; cell proliferation; cell viability; chromosome 15; colony formation; DNA methylation; epigenetics; epithelial mesenchymal transition; exosome; gene expression profiling; gene regulatory network; genetic transcription; human; human cell; liver cell carcinoma; luciferase assay; MAPK signaling; mouse; nonhuman; ovary cancer; protein expression; protein function; protein RNA binding; renal cell carcinoma; Review; RNA sequence; Streptomyces; transcription regulation; tumor associated leukocyte; tumor xenograft; Warburg effect; cell motion; female; gene regulatory network; genetics; metabolism; neovascularization (pathology); ovary tumor; vascularization; Cell Movement; Female; Gene Regulatory Networks; Humans; MicroRNAs; Neovascularization, Pathologic; Ovarian Neoplasms; RNA, Long Noncoding; RNA, Neoplasm
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