abstract

• Introduction: Rafts are function-structural cell membrane nano-domains. They contribute to explain the efficiency of signal transduction at the low physiological membrane concentrations of the signaling partners by their clustering inside specialized signaling domains. Development: In this article, we review the current model of the membrane rafts and their physio-pathological relevance in the nervous system, including their role in Parkinson, Alzheimer, and Huntington diseases. Conclusions: Rafts disruption/dysfunction has been shown to relate diverse neurological diseases. Therefore, it has been suggested that preservation of membrane rafts may represent a strategy to prevent or delay neuronal dysfunctions in several diseases. © 2021 Sociedad Española de Neurología

authors

• Meza U.
• Rodríguez Menchaca Aldo Azmar
• Romero-Méndez C.
• Sánchez Armass Acuña Sergio Ramón

publication date

• 2021-01-01

published in

• Neurologia  Journal

keywords

• Alzheimer; Caveolae; Cell membrane; Cholesterol; Huntington; Parkinson

Digital Object Identifier (DOI)

• 10.1016/j.nrl.2021.01.008

PubMed ID

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