Magnetic nanoparticle behavior evaluation on cardiac tissue contractility through Langendorff rat heart technique as a nanotoxicology parameter Article uri icon

abstract

  • Magnetic nanoparticles (MNP) and silicon-decorated magnetic nanoparticles (SMNP) have been the object of interest in numerous industry fields as diverse as information storage, diagnostics and imaging, and water treatment thanks to their magnetic properties, which confer them the ability to navigate remotely to a specific location, retrieve material, and vibrate without harmful radiation. However, like all chemical agents, the nanoparticles require pinpoint regulations to ensure proper handling, use, and disposal once their use is finished. The human body%27s exposition can lead to unknown effects once these particles reach internal structures, like the vascular system. The results show that concentrations of MNP (1–1000 μg/ml) induced alteration on the cardiovascular physiology, on the cardiac contractility, and in the perfusion pressure. Parameters that also were associated with the alteration on nitric oxide (NO) levels, a free radical which regulate the vascular tone, effects displayed from the first administration of the lowest concentration derived from a sustained constriction, which also induced inhibition of the relaxation by the vasoactive substance acetylcholine (ACh), and the blockage of norepinephrine (NE), respectively. © 2021, King Abdulaziz City for Science and Technology.
  • Magnetic nanoparticles (MNP) and silicon-decorated magnetic nanoparticles (SMNP) have been the object of interest in numerous industry fields as diverse as information storage, diagnostics and imaging, and water treatment thanks to their magnetic properties, which confer them the ability to navigate remotely to a specific location, retrieve material, and vibrate without harmful radiation. However, like all chemical agents, the nanoparticles require pinpoint regulations to ensure proper handling, use, and disposal once their use is finished. The human body's exposition can lead to unknown effects once these particles reach internal structures, like the vascular system. The results show that concentrations of MNP (1–1000 μg/ml) induced alteration on the cardiovascular physiology, on the cardiac contractility, and in the perfusion pressure. Parameters that also were associated with the alteration on nitric oxide (NO) levels, a free radical which regulate the vascular tone, effects displayed from the first administration of the lowest concentration derived from a sustained constriction, which also induced inhibition of the relaxation by the vasoactive substance acetylcholine (ACh), and the blockage of norepinephrine (NE), respectively. © 2021, King Abdulaziz City for Science and Technology.

publication date

  • 2021-01-01