abstract

• Chitosan is a natural polymer that can sustain not only osteoblast adhesion and proliferation for bone regeneration purposes, but it is also claimed to exhibit antibacterial properties towards several Gram-positive and Gram-negative bacteria. In this study, chitosan was modified with sodium hyaluronate, crosslinked with polyethylene glycol diglycidyl ether (PEGDE) and both osteoblast cytotoxicity and antibacterial behavior studied. The presence of sodium hyaluronate and PEGDE on chitosan was detected by FTIR, XRD, and XPS. Chitosan (CHT) films with sodium hyaluronate crosslinked with PEGDE showed a better thermal stability than pristine hyaluronate. In addition, osteoblast cytocompatibility improved in films containing sodium hyaluronate. However, none of the films exhibit antimicrobial activity against Escherichia coli, Enterococcus faecalis, and Staphylococcus aureus while exhibiting low to mild activity against Salmonella typhimurion. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

authors

• Cauich-Rodríguez J.V.
• Chuc-Gamboa M.G.
• Escobar García Diana María
• Pacheco N.
• Sánchez Vargas Luis Octavio
• Vargas-Coronado R.F.

publication date

• 2021-01-01

funding provided via

• Consejo Nacional de Ciencia y Tecnología, CONACYT: 1360, 248378, 268595, 283972, 339277  Grant

published in

• Applied Sciences (Switzerland)  Journal

keywords

• Antibacterial; Chitosan; Enterococcus faecalis; Escherichia coli; PEGDE; Salmonella typhimurion; Sodium hyaluronate; Staphylococcus aureus

Digital Object Identifier (DOI)

• 10.3390/app11031267

PubMed ID

start page

• 1

end page

• 21

volume

• 11

issue

• 3