Plant-based vaccines against respiratory diseases: current status and future prospects

Introduction: Respiratory infections have an enormous, worldwide epidemiologic impact on humans and animals. Among the prophylactic measures, vaccination has the potential to neutralize this impact. New technologies for vaccine production and delivery are of importance in this field since they offer the potential to develop new immunization approaches overriding the current limitations that comprise high cost, safety issues, and limited efficacy. Areas covered: In the present review, the state of the art in developing plant-based vaccines against respiratory diseases is presented. The review was based on the analysis of current biomedical literature. Expert commentary: Preclinical and clinical evaluations of several vaccine candidates against influenza, tuberculosis, respiratory syncytial virus, pneumonia, anthrax and asthma are discussed and placed in perspective. © 2016 Informa UK Limited, trading as Taylor %26 Francis Group.

Bronchus associated lymphoid tissue; cellular immunity; molecular pharming; oral immunization; parenteral immunization; subunit vaccine plant based vaccine; unclassified drug; vaccine; bacterial vaccine; recombinant vaccine; virus vaccine; anthrax; asthma; Bacillus anthracis; clinical evaluation; human; immunization; influenza; Mycobacterium tuberculosis; nonhuman; pneumonia; priority journal; respiratory syncytial virus infection; respiratory tract disease; Review; Streptococcus pneumoniae; tuberculosis; animal; clinical trial (topic); disease model; drug development; genetics; immunology; isolation and purification; metabolism; preclinical study; Respiratory Tract Infections; transgenic plant; trends; Animals; Bacterial Vaccines; Clinical Trials as Topic; Disease Models, Animal; Drug Discovery; Drug Evaluation, Preclinical; Humans; Plants, Genetically Modified; Respiratory Tract Infections; Vaccines, Synthetic; Viral Vaccines

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