abstract

• Phytochemical investigation of the leaves and flowers from Salvia hirsuta led to the isolation of the five microphyllane-type diterpenoids (1–5), and two flavones (6–7). Hirsutolides constituted new diterpenoids containing a 5-hydroxyfuran-2(5H)-one and were isolated as an epimeric mixture at C-3 and C-15. The structures of the isolated compounds were established through the analysis of their NMR spectroscopic and MS spectrometric data; and confirmed by single-crystal X-ray diffraction studies. Cytotoxic and MDR modulatory activities of compounds 1–5 were determined. © 2019 Elsevier B.V.

authors

• Bautista-Redonda F.E.
• Cárdenas J.
• Fragoso-Serrano M.
• García-Peña M.D.R.
• Ortega A.
• Ortiz-Pastrana N.
• Pérez Vázquez Francisco Javier
• Toscano R.A.

publication date

• 2020-01-01

funding provided via

• Consejo Nacional de Ciencia y Tecnología, CONACYT: CB220535, FORDECYT-CIIDZA 296354  Grant
• Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México, DGAPA, UNAM  Grant
• Universidad Nacional Autónoma de México, UNAM: IN208019  Grant

published in

• Journal of Molecular Structure  Journal

keywords

• Diastereomers; Hirsutolides; Lamiaceae; Mycrophyllane diterpenoids; Salvia hirsuta; Solid solution Isomers; Lipids; Single crystals; Spectroscopic analysis; X ray diffraction; Diastereomers; Diterpenoids; Hirsutolides; Lamiaceae; Salvia hirsuta; Solid solutions

Digital Object Identifier (DOI)

• 10.1016/j.molstruc.2019.127409

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volume

• 1203