Altered NK cell receptor repertoire and function of natural killer cells in patients with acute myocardial infarction: A three-month follow-up study
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NK cells are important in the onset of acute myocardial infarction (AMI) by their ability to secrete IFN-γ and other inflammatory cytokines. They also participate in regulating pathological cardiac remodeling after myocardial infarction. Mechanisms of regulation, however, are incompletely understood. Herein, the aim of this study is to explore the possible association between the expression pattern of different NK cell receptors (phenotype), as well as the cytotoxic function of NK cells from AMI patients with their myocardial function after three months follow-up. We analyzed the phenotype and function of both CD56dimCD16%2b and CD56brightCD16− NK cells from twenty-one patients within the first 72 h after ST-elevation AMI and three-month follow-up, as well as fifteen healthy controls. Clinical characteristics and ventricular function determined by echocardiography were also evaluated. NK cells from AMI patients showed an activated phenotype, characterized by high TNF-α production and low percentages of the activating receptor NKG2D. Interestingly, AMI patients display higher levels of circulating IL-10%2b NK cells. Three-month follow-up showed that NK cells exhibit a diminished cytotoxic function. These data show that NK cells may have a role mediating myocardial remodeling by regulating the inflammatory response, mainly by the production of IL-10. We also propose that NKG2D may have a role in the onset of the inflammatory response immediately after AMI. The precise regulation of NK cells function may represent an important step in recovery of myocardial function. © 2020 Elsevier GmbH
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Acute myocardial infarction; Cardiac remodeling; Cytokines; Natural killer cells; NK receptors B7 antigen; CD16 antigen; CD3 antigen; CD56 antigen; CD86 antigen; cholesterol; high density lipoprotein; ILT2 protein; interleukin 10; low density lipoprotein; lymphocyte receptor; natural cytotoxicity triggering receptor 1; natural cytotoxicity triggering receptor 2; natural killer cell receptor; natural killer cell receptor NKG2A; natural killer cell receptor NKG2C; natural killer cell receptor NKG2D; triacylglycerol; tumor necrosis factor; unclassified drug; acute heart infarction; adult; Article; cardiovascular disease assessment; cholesterol blood level; clinical article; controlled study; correlation analysis; cytokine production; cytotoxicity; Doppler echocardiography; female; flow cytometry; follow up; heart left ventricle ejection fraction; heart left ventricle enddiastolic volume; heart ventricle function; human; human cell; lipoprotein blood level; lymphocyte function; male; natural killer cell; priority journal; protein expression; ST segment elevation myocardial infarction; thrombolysis in myocardial infarction score; triacylglycerol blood level
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