Curcumin provides hepatoprotection against amoebic liver abscess induced by entamoeba histolytica in hamster: Involvement of Nrf2/HO-1 and NF-κB/IL-1β signaling pathways
Article
Overview
Research
Identity
Additional Document Info
View All
Overview
abstract
Amoebic liver abscess (ALA) is the most common extraintestinal amoebiasis caused by Entamoeba histolytica (E. histolytica). However, despite current knowledge and scientific advances about this infection, there are no effective treatments to prevent it. Herein, the antiamoebic capacity of curcumin in a hamster model was evaluated. Curcumin (150 mg/kg, p.o., daily during 10 days before infection) considerably prevents liver damage induced at 12 and 48 h post-intrahepatic inoculation of trophozoites and decreases ALT, ALP, and γ-GTP activities, and macroscopic and microscopic observations were consistent with these results. On the other hand, after one week of intraportal inoculation, liver damage was prevented by curcumin (150 mg/kg, p.o., daily, 20 days before amoebic inoculation and during the week of infection); liver/body weight ratios and tissue and histological stains showed normal appearance; in addition, the increases in ALT, ALP, and γ-GTP activities were prevented; the depletion of glycogen content induced by the amoebic damage was partially but significantly prevented, while NF-κB activity was inhibited and the expression of IL-1β was reduced; Nrf2 production showed a tendency to increase it, and HO-1 protein was overexpressed. These results suggest for the first time that curcumin can be a compound with antiamoebic effect in the liver, suggesting that its daily use could help greatly decrease the incidence of this type of infection. Copyright © 2019 José Roberto Macías-Pérez et al.
publication date
published in
Research
keywords
alanine aminotransferase; alkaline phosphatase; curcumin; gamma glutamyltransferase; glycogen; heme oxygenase 1; immunoglobulin enhancer binding protein; interleukin 1beta; transcription factor Nrf2; curcumin; heme oxygenase 1; immunoglobulin enhancer binding protein; interleukin 1beta; nonsteroid antiinflammatory agent; protective agent; transcription factor Nrf2; animal experiment; animal model; antiamoebic activity; Article; controlled study; cytokine production; enzyme activity; glycogen analysis; inoculation; liver amebiasis; liver protection; nonhuman; protein expression; signal transduction; animal; biopsy; Entamoeba histolytica; hamster; human; liver; liver amebiasis; male; metabolism; parasitology; pathology; severity of illness index; signal transduction; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Cricetinae; Curcumin; Entamoeba histolytica; Heme Oxygenase-1; Humans; Interleukin-1beta; Liver; Liver Abscess, Amebic; Male; NF-E2-Related Factor 2; NF-kappa B; Protective Agents; Severity of Illness Index; Signal Transduction
Identity
Digital Object Identifier (DOI)
PubMed ID
Additional Document Info
start page
end page
volume