abstract

• Nowadays, regenerative medicine has paid special attention to research (in vitro and in vivo) related to bone regeneration, specifically in the treatment of bone fractures or skeletal defects, which is rising worldwide and is continually demanding new developments in the use of stem cells, growth factors, membranes and scaffolds based on novel nanomaterials, and their applications in patients by using advanced tools from molecular biology and tissue engineering. Strontium (Sr) is an element that has been investigated in recent years for its participation in the process of remodeling and bone formation. Based on these antecedents, this is a review about the Strontium Folate (SrFO), a recently developed non-protein based bone-promoting agent with interest in medical and pharmaceutical fields due to its improved features in comparison to current therapies for bone diseases. © 2019 by the authors.

authors

• Flores-Cedillo M.L.
• Martin-del-Campo M.B.
• Rojo L.
• Rosales-Ibañez R.
• Sampedro Pérez José Guadalupe

publication date

• 2019-01-01

published in

• Molecules  Journal

keywords

• Bone regeneration; Musculoskeletal defects; Strontium folate biomaterial; cyanocobalamin; folic acid; pyridoxine; strontium; animal; bone; bone development; bone regeneration; chemistry; cytology; drug effect; human; metabolism; physiology; stem cell; synthesis; tissue engineering; tissue scaffold; tooth pulp; Animals; Biocompatible Materials; Bone and Bones; Bone Regeneration; Dental Pulp; Folic Acid; Humans; Osteogenesis; Stem Cells; Strontium; Tissue Engineering; Tissue Scaffolds; Vitamin B 12; Vitamin B 6

Digital Object Identifier (DOI)

• 10.3390/molecules24091660

PubMed ID

• 31035627

start page

end page

volume

• 24

issue

• 9