abstract

• Nanoheaters are promising tools for localized photothermal therapy (PTT) of malignant cells. The anisotropic AuNPs present tunable surface plasmon resonances (SPR) with ideal NIR optical response to be applied as theranostic agents. To this purpose, nanoparticles with branches are suitable because of the electromagnetic field concentrated at their vertices. We standardized a protocol to synthesize multibranched gold nanoparticles (MB-AuNPs) by the seed-growth method and found a size-seed dependence tunability on the hierarchy of branching. Once the optical response is evaluated, we tested the temporal stability as nanoheaters of the MB-AuNPs immersed in skin-equivalent phantoms by dynamic infrared thermography (DIRT). The most suited sample presents a concentration of 5.2×108 MB-AuNPs/mL showing good thermal stability with ΔT = 4.5°C, during 3 cycles of 10 min at 785 nm laser irradiation with power of 0.15 W. According to these results, the MB-AuNPs are suitable nanoheaters to be tested for PTT in more complex models. © 2018 K. A. López-Varela et al.

authors

• Cayetano-Castro N.
• Chiwo F.S.
• González Contreras Francisco Javier
• Kolosovas Machuca Eleazar Samuel
• López-Varela K.A.
• Rodríguez-López J.L.

publication date

• 2018-01-01

funding provided via

• 106437, 216315  Grant
• National Energy Technology Laboratory  Grant

keywords

• Electromagnetic fields; Gold nanoparticles; Nanoparticles; Surface plasmon resonance; Synthesis (chemical); Thermography (imaging); Complex model; Malignant cells; Optical response; Photothermal therapy; Seed growth method; Skin equivalents; Temporal stability; Theranostic agents; Phantoms

Digital Object Identifier (DOI)

• 10.1155/2018/3847348

start page

end page

volume

• 2018