Transplastomic plants yield a multicomponent vaccine against cysticercosis
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Low cost vaccines against cysticercosis are needed to fight this parasitosis, especially in developing countries. Herein polycistron arrangements were designed to accomplish the simultaneous expression of multiple protective antigens from Taenia solium in the plant cell as an attractive biofactory and delivery vehicle of vaccines. Transplastomic plants carrying synthetic polycistrons were able to simultaneously express the KETc1, KETc7, KETc12, GK1, and TSOL18/HP6-Tsol antigens; which retained their antigenicity and ability to induce humoral responses in BALB/c mice. These clones may be useful for the production of low-cost cysticercosis vaccine prototypes. © 2017 Elsevier B.V.
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Chloroplast expression; Plant-based vaccine; Polycistron; S3Pvac vaccine; Taenia solium Antigens; Developing countries; Antigenicity; Biofactories; Chloroplast expression; Delivery vehicle; Multicomponents; Polycistron; Protective antigens; Taenia solium; Vaccines; antigen; DNA; vaccine; parasite antigen; antigen expression; antigenicity; Article; cistron; cysticercoid; cysticercosis; enzyme linked immunosorbent assay; experimental pig; high performance liquid chromatography; humoral immunity; immunization; mouse; nonhuman; plant; plant cell; priority journal; reverse transcription polymerase chain reaction; Taenia solium; transplastomic plant; Western blotting; animal; biosynthesis; cysticercosis; genetics; immunology; Leporidae; metabolism; Taenia solium; tobacco; transgenic plant; Animals; Antigens, Helminth; Cysticercosis; Plants, Genetically Modified; Rabbits; Taenia solium; Tobacco; Vaccines
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