abstract

• A drug delivery system (DDS) with analgesic and antibacterial properties would be desirable for the local control of post-operatory pain and the prevention for surgical site infection (SSI). The objective of the present study was to evaluate the antinociceptive effect of the combination between dexketoprofen trometamol (DXT) and chlorhexidine gluconate (CHX) in the formalin pain model. Different doses of CHX were combined with DXT and were locally administered in rats paw simultaneously with 5%25 formalin dilution. Flinches were documented and the antinociceptive effect was calculated. The area under the curve of each experimental group were calculated and the %25 of antinociception were compared. The groups of CHX and DXT showed similar antinociceptive effect. The combination groups (DXT-CHX) showed higher antinociceptive effect that the one obtained with individual molecules. Besides the confirmation of DXT local antinociceptive properties, CHX also showed a positive effect; and an additive effect when combined with DXT. © 2018, Faculdade de Ciencias Farmaceuticas (Biblioteca). All rights reserved.

authors

• Chavarria-Bolaños D.
• Esparza-Villalpando V.
• Pozos Guillén Amaury de Jesús
• Vértiz Hernández Ángel Antonio
• Zapata-Morales J.R.

publication date

• 2018-01-01

funding provided via

• Consejo Nacional de Ciencia y Tecnología, CONACYT: 599447/326741  Grant
• Universidad Autónoma de San Luis Potosí, UASLP: C18-FAI-05-50.50  Grant

published in

• Brazilian Journal of Pharmaceutical Sciences  Journal

keywords

• Antinociception/effects; Chlorhexidine; Dexketoprofen trometamol; Formalin test chlorhexidine gluconate; chx; dexketoprofen; dxt; analgesia; animal experiment; animal model; animal tissue; antinociception; area under the curve; Article; controlled study; drug potentiation; female; formalin test; intermethod comparison; molecule; nonhuman; pain; rat; surgical infection

Digital Object Identifier (DOI)

• 10.1590/s2175-97902018000217799

start page

end page

volume

• 54

issue

• 2