abstract

• 22 patients with postoperative pain received a single 30 mg dose of ketorolac tromethamine, im. Ketorolac plasma concentration and analgesic effect were determined simultaneously. Pain relief was evaluated by a five-point verbal rating scale. All patients reported an analgesic effect. However, the appearance of the effect was delayed with regard to plasma concentration. Effect against plasma concentration curves exhibited a counterclockwise hysteresis loop, showing that there is no direct relationship. Hence, the effect was related to drug concentration in an effect compartment by pharmacokinetic-pharmacodynamic modelling. Drug transfer from the central to the effect compartment was described by a k of 3.42xlO~4 h. Additionally, effect compartment concentrations were related to the probability of observing a moderate, sufficient and total pain relief by logistic analysis, a good correlation being obtained in the three cases. Results show a very good analgesic efficacy for ketorolac. The probabilities of obtaining a sufficient and a total pain relief with the effect compartment concentrations achieved with the 30 mg (im) dose were about 100%25 and 70%25 respectively.

authors

• Castañeda-Hernández G.
• Flores-Murrieta F.J.
• Gonzalez C.
• Granados-Soto V.
• Hong E.
• Martinez J.L.
• Pérez-Urizar J.

publication date

• 1996-01-01

published in

• Proceedings of the Western Pharmacology Society  Journal

start page

• 99

end page

volume

• 39