Impact of vaccination on influenza mortality in children <5 years old in Mexico
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Background Influenza is a leading cause of respiratory tract infections among children. In Mexico, influenza vaccination was included in the National Immunization Program since 2004. However, the population health effects of the vaccine on children have not been fully described. Thus, we estimated the impact of influenza immunization in terms of mortality associated with this virus among children younger than 5 years of age in Mexico. Methods Mortality rates and years of life lost associated with influenza were estimated using national mortality register data for the period 1998–2012. Age-stratified and cause-specific mortality rates were estimated for all-cause, respiratory and cardiovascular events. Influenza-associated mortality was compared between the period prior to introduction of the influenza vaccine as part of the National Immunization Program (1998–2004) and the period thereafter (2004–2012). Results During the 1998–2012 winter seasons, the average number of all-cause, respiratory and cardiovascular deaths attributable to influenza were 1186, 794 and 21, respectively. Influenza-associated mortality was higher prior to the vaccination period than after influenza was included in the immunization program for all-cause (mean 1660 vs. 780) and respiratory (mean 1063 vs. 563) mortality, but no reduction was seen for cardiovascular mortality. The proportion of all-cause and respiratory deaths attributable to influenza was significantly lower in the post-vaccine period compared with the pre-vaccine period (P < 0.001), but no reduction was seen in the proportion of cardiovascular deaths. There was an average annual reduction of 66,558 years of life lost in the post-vaccine compared with the pre-vaccine period. Conclusion The introduction of influenza vaccination within the Mexican Immunization Program was associated with a reduction in mortality rates attributable to this virus among children younger than 5 years of age. © 2017 Elsevier Ltd
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Immunization; Influenza; Mortality; Respiratory tract infections; Vaccines influenza vaccine; influenza vaccine; age; Article; cardiovascular mortality; child; childhood mortality; human; infant; influenza; influenza vaccination; major clinical study; Mexico; mortality rate; mortality risk; priority journal; respiratory tract infection; risk reduction; female; influenza; male; mortality; preschool child; preventive health service; respiratory tract infection; season; vaccination; virology; virus pneumonia; Child, Preschool; Female; Humans; Immunization Programs; Influenza Vaccines; Influenza, Human; Male; Mexico; Pneumonia, Viral; Respiratory Tract Infections; Seasons; Vaccination
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