FormylBODIPYs: Privileged Building Blocks for Multicomponent Reactions. the Case of the Passerini Reaction
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Eleven formyl-containing BODIPY dyes were prepared by means of either the Liebeskind-Srogl cross-coupling reaction or the Vilsmeier reaction. These dyes were used as components in the Passerini reaction to give highly substituted BODIPY dyes. A joined spectroscopic and theoretical characterization of the synthesized compounds was conducted to unravel the impact of the structural rigidity/flexibility on the photophysical signatures. These dyes were tested as fluorescent trackers for phagocytosis. Additionally, they proved to be useful to stain different blood cells with an intense and stable signal at a very low exposure time. © 2016 American Chemical Society.
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Antigen-antibody reactions; Blood cells; Bodipy dyes; Building blockes; Cross coupling reactions; Exposure-time; Multi-component reactions; Photophysical; Structural rigidity; Chemical reactions; blood cell; exposure; phagocytosis; rigidity; stain; substitution reaction; theoretical model; cell phagocytosis; chemical structure; chemistry; drug effects; ultraviolet spectrophotometry; 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; boron derivative; fluorescent dye; Boron Compounds; Cytophagocytosis; Fluorescent Dyes; Molecular Structure; Spectrophotometry, Ultraviolet
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