Antiprotozoal activity of extracts of elaeodendron trichotomum (Celastraceae)
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Background: Chagas disease, amebiasis, giardiasis and trichomoniasis represent a serious health problem in Latin America. The drugs employed to treat these illnesses produce important side effects and resistant strains have appeared. The present study was aimed to evaluate the antiprotozoal activity of leaves, stem bark and root bark of Elaeodendron trichotomum, a celastraceus, that is used in Mexico as an anti-infective in febrile-type diseases. Materials and methods: Dichloromethane and methanol extracts of leaves, bark and roots of Elaeodendron trichotomum were tested against Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis, and Trypanosoma cruzi. A quantitative HPLC analysis of pristimerin and tingenone was performed. Results: The dichloromethane extract of roots was active against E. histolytica, G. lamblia, T. vaginalis, and T. cruzi, at IC50’s of 0.80, 0.44, 0.46, and 2.68 μg/mL, respectively. The HPLC analysis revealed the presence of tingenone (3.84%25) and pristimerin (0.14%25). Conclusions: The dichloromethane extract of the roots bark showed significant activity against all screened protozoa. © 2016, African Ethnomedicines Network. All rights reserved.
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Antiprotozoal activity; Celastraceae; Elaeodendron trichotomum; Pristimerin; Root bark; Tingenone antiprotozoal agent; dichloromethane; Elaeodendron trichotomum extract; metronidazole; plant extract; pristimerin; tingenone; triterpenoid; unclassified drug; antiprotozoal agent; plant extract; antiprotozoal activity; Article; bacterial strain; bark; Celastraceae; controlled study; drug screening; Elaeodendron trichotomum; Entamoeba histolytica; Giardia intestinalis; high performance liquid chromatography; IC50; in vitro study; limit of detection; limit of quantitation; nonhuman; plant leaf; plant root; Trichomonas vaginalis; Trypanosoma cruzi; chemistry; drug effects; drug sensitivity; isolation and purification; Mexico; Antiprotozoal Agents; Celastraceae; Entamoeba histolytica; Giardia lamblia; Mexico; Parasitic Sensitivity Tests; Plant Bark; Plant Extracts; Plant Leaves; Plant Roots; Trypanosoma cruzi
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