Antibacterial and antifungal activity of Salvia apiana against clinically important microorganisms [Actividad antibacteriana y antifúngica de un extracto de Salvia apiana frente a microorganismos de importancia clínica]

Due to the great global concern regarding bacterial resistance to antibiotics, an ongoing search for new molecules having antibacterial activity is necessary. This study evaluated the antibacterial and anticandidal effects of a hexane extract from the root of Salviaapiana. Salvia extracts at concentrations of 27, 13.5, 6.8 and 3.4 mg/ml caused growth inhibition of Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecalis and Candidaalbicans. However, no significant effect was observed on Escherichia coli and Candida tropicalisin comparison to vehicle. It was here demonstrated for the first time that Salvia apiana has an important antimicrobial effect on human pathogens of great clinical value, thus opening the field to continue the evaluation of this lamiaceous plant for its future use as a therapeuticagent. © 2016 Asociación Argentina de Microbiología.

Gram-negative bacteria; Gram-positive bacteria; Salvia apiana; Yeast antibiotic agent; antifungal agent; antiinfective agent; hexane; n-hexane; plant extract; solvent; antibacterial activity; antibiotic resistance; antifungal activity; Article; Candida albicans; Candida tropicalisin; controlled study; Enterococcus faecalis; Escherichia coli; nonhuman; Staphylococcus aureus; Streptococcus pyogenes; Candida; chemistry; comparative study; disk diffusion; dose response; drug effects; Gram negative bacterium; Gram positive bacterium; isolation and purification; plant root; preclinical study; Salvia; species difference; Anti-Bacterial Agents; Antifungal Agents; Candida; Disk Diffusion Antimicrobial Tests; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Gram-Negative Bacteria; Gram-Positive Bacteria; Hexanes; Plant Extracts; Plant Roots; Salvia; Solvents; Species Specificity

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