Evaluation of acute toxicity in vivo of ethanolic and aqueous extracts of Calea urticifolia [Evaluación de la toxicidad aguda in vivo del extracto etanólico y acuoso de Calea urticifolia]

Calea urticifolia is recognized for its value in the treatment of diseases associated with inflammatory processes; however, despite the scientific corroboration of its traditional effect, there is no evidence of toxicological studies of the species widely used in traditional medicine Xi%26#39;iuy of San Luis Potosi, Mexico. This study considered to assess the acute toxicity of ethanolic and aqueous extracts of the leaves of Calea urticifolia. Both sexes of Wistar rats were used to determine the LD50using the alternative oral acute toxic class method. The fixed doses evaluated in this study were 50, 100, 300, 1,000, 2,000, and 5,000 mg/kg. We evaluated changes in body weight gain and parameters of renal and liver functionality. The results showed a LD50> 1,000 mg/kg for the ethanolic extract and > 5,000 mg/kg for the aqueous extract, without signs and symptoms of acute toxicity, in addition no alterations in body weight gain were detected. The serum concentration of urea, creatinine and serum transaminase levels showed no significant changes compared with the control group. Based in these results, the species is classified in the category 4 in its ethanolic extract and as category 5 in the aqueous extract, accordint to GHS (Globally Harmonized Classification System). © 2016, Sociedad Botanica de Mexico, A.C. All rights reserved.

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