Modulation of Kv2.1 channels inactivation by curcumin Article uri icon

abstract

  • Background The aim of the present study was to assess the effects of curcumin on the voltage-dependent Kv2.1 potassium channel. Methods The whole-cell patch-clamp technique was used to explore the regulation of Kv2.1 channels expressed in HEK293 cells by curcumin. Results Curcumin reduced the Kv2.1 currents; the inhibition occurred with a slow time course and was partially reversible. Curcumin did not alter the kinetics and voltage dependence of activation; however, the kinetics of open- and closed-state inactivation was accelerated by curcumin along with a hyperpolarizing shift in the voltage dependence of inactivation. Curcumin inhibition of Kv2.1 current was not use-dependent. Conclusions Overall, our data suggest that curcumin inhibits Kv2.1 channels by modulating the inactivation gating, which would be expected to impact cellular physiology. © 2015 Institute of Pharmacology, Polish Academy of Sciences.

publication date

  • 2015-01-01