Eczema herpeticum in a patient with atopic dermatitis, carrying R501X and 2282del4 filaggrin null mutations [Eccema herpético en un paciente con dermatitis atópica, portador de las mutaciones R501X y 2282del4 en el gen de la filagrina]

Eczema herpeticum is an acute dermatoses caused by herpes simplex virus type 1 in atopic dermatitis patients, and is considered a dermatology emergency. Eczema herpeticum occurs in less than 3[%25] of atopic patients. We report a patient with a history of atopic dermatitis who presented to an emergency department with eczema herpeticum. He was admitted and treated with antiviral medications with good outcome. We investigated filaggrin null mutations in the patient and his family and correlate them with the severity of the disease. We present the first Mexican patient with eczema herpeticum, atopic dermatitis and the presence of R501X and 2282del4 filaggrin null mutations. © 2015, Academia Nacional de Medicina. All rights reserved.

antivirus agent; filaggrin; filaggrin; intermediate filament protein; Article; atopic dermatitis; case report; disease severity; emergency ward; gene mutation; Herpes simplex virus 1; human; Kaposi varicelliform eruption; male; null allele; treatment outcome; adolescent; atopic dermatitis; complication; genetics; Kaposi varicelliform eruption; mutation; pedigree; Adolescent; Adolescent; Dermatitis, Atopic; Dermatitis, Atopic; Humans; Humans; Intermediate Filament Proteins; Intermediate Filament Proteins; Kaposi Varicelliform Eruption; Kaposi Varicelliform Eruption; Male; Male; Mutation; Mutation; Pedigree; Pedigree

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