Lipid peroxidation and the response of the antioxidant defense system in the obese type 2 diabetic compared with the non-obese type 2 diabetic [peroxidación de lípidos y la respuesta del sistema de defensa antioxidante en el diabético tipo 2 obeso en comparación al diabético tipo 2 sin obesidad]
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Introduction: Diabetes is associated with increased lipid peroxidation, quantified as the levels of thiobarbituric acid reactive substances (TBARS). In parallel, the antioxidant defense system (ADS) reacts to diminish the oxidative damage. Objective: To determine the levels of lipid peroxidation and the activity of antioxidant enzymes in obese type 2 diabetic (DM2) individuals compared to non-obese DM2 individuals. Methods: Lipid peroxidation was quantified by measuring TBARS and the ADS response by measuring the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Results: Two groups of 30 subjects were studied. The obese DM2 group had a mean body mass index (BMI) 38.6 ± 3.5 kg m-2 compared to the control group 24.7 ± 3.6 kg m-2 (p<0.01). TBARS levels in the study group were higher compared to the control group (p <0.01). Multiple linear regression analysis suggested that activities of SOD and CAT adjusted to lipid peroxidation (TBARS) in the obese DM2 individuals. Conclusion: TBARS levels suggest greater oxidative damage in obese DM2 subjects with a diminished response of ADS.
