The Chemopreventive Capacity of Quercetin to Induce Programmed Cell Death in Hepatocarcinogenesis Article uri icon

abstract

  • In this study of chemoprevention in the rat modified resistant hepatocyte model, preneoplastic cells were diminished by >60%25 with quercetin pretreatment compared with those rats treated with N-Diethylnitrosamine (DEN) to induce liver cancer. This decrease occurred associated with an abolished DEN-induced lipid peroxidation as well as activation of caspase 9 and increased caspase 3, as determined by increased expression of cleaved caspase 3 and 9, but not cleaved caspase 8 and increased fragmentation of Poly (ADP-ribose) polymerase (PARP) inducing apoptosis of presumed genetically injured cells, when quercetin was administered before the initiation agent. © 2012, SAGE Publications. All rights reserved.

publication date

  • 2013-01-01