Antidiabetic effects of Justicia spicigera Schltdl (Acanthaceae)
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Ethnopharmacological importance: Justicia spicigera is a plant species used for the Teenak (Huesteca Potosina) and Mayan (Yucatan peninsula) indigenous for the empirical treatment of diabetes, infections and as stimulant. Aim of the study: To evaluate the cytotoxicity, antioxidant and antidiabetic properties of J. spicigera. Materials and methods: The effects of ethanolic extracts of J. spicigera (JSE) on the glucose uptake in insulin-sensitive and insulin-resistant murine 3T3-F442A and human subcutaneous adipocytes was evaluated. The antioxidant activities of the extract of JSE was determined by ABTS and DPPH methods. Additionally, it was evaluated the antidiabetic properties of JSE on T2DM model. Results: JSE stimulated 2-NBDG uptake by insulin-sensitive and insulin-resistant human and murine adipocytes in a concentration-dependent manner with higher potency than rosiglitazone 1 mM. JSE showed antioxidant effects in vitro and induced glucose lowering effects in normoglycemic and STZ-induced diabetic rats. Conclusion: The antidiabetic effects of administration of J. spicigera are related to the stimulation of glucose uptake in both insulin-sensitive and insulin-resistant murine and human adipocytes and this evidence justify its empirical use in Traditional Medicine. In addition, J. spicigera exerts glucose lowering effects in normoglycemic and STZ-induced diabetic rats. © 2012 Elsevier Ireland Ltd.
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Antioxidant; Cytotoxic; Diabetes; Glucose uptake; Justicia spicigera antidiabetic agent; glibenclamide; glucose; Justicia spicigera extract; plant extract; repaglinide; rosiglitazone; saxagliptin; unclassified drug; adipocyte; animal cell; animal experiment; animal model; antidiabetic activity; antioxidant activity; article; controlled study; cytotoxicity; drug efficacy; drug potency; glucose blood level; glucose transport; human; human cell; in vitro study; in vivo study; Justicia spicigera; male; medicinal plant; nonhuman; rat; streptozocin diabetes; 3T3 Cells; 4-Chloro-7-nitrobenzofurazan; Acanthaceae; Adipocytes; Animals; Antioxidants; Benzothiazoles; Cell Survival; Cells, Cultured; Deoxyglucose; Diabetes Mellitus, Experimental; Ethanol; Glucose; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Kaempferols; Male; Mice; Phytotherapy; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Solvents; Sulfonic Acids; Acanthaceae; Justicia spicigera; Murinae; Rattus
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