Preparation and bactericide activity of gallic acid stabilized gold nanoparticles
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In this work, gold nanoparticles with three different sizes (13.7, 39.4, and 76.7 nm) were prepared using a simple aqueous method with gallic acid as the reducing and stabilizing agent, the different sizes were obtained varying some experimental parameters as the pH of the reaction and the amount of the gallic acid. The prepared nanoparticles were characterized using X-ray diffraction, transmission electron microscopy, dynamic light scattering, and UV-Vis spectroscopy. Samples were identified as elemental gold and present spherical morphology, a narrow size distribution and good stabilization according to TEM and DLS results. The antibacterial activity of this gallic acid stabilized gold nanoparticles against S. mutans (the etiologic agent of dental caries) was assessed using a microdilution method obtaining a minimum inhibitory concentration of 12.31, 12.31, and 49.25 μg/mL for 13.7, 39.4, and 76.7 nm gold nanoparticles, respectively. The antibacterial assay showed that gold nanoparticles prepared in this work present a bactericide activity by a synergistic action with gallic acid. The MIC found for this nanoparticles are much lower than those reported for mixtures of gold nanoparticles and antibiotics. © 2010 Springer Science%2bBusiness Media B.V.
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Bactericide; Gallic acid; Gold nanoparticles; Nanobiomedicine; Synthesis Bactericides; Dynamic light scattering; Fiber optic sensors; Gold alloys; High resolution transmission electron microscopy; Metal nanoparticles; Synthesis (chemical); Transmission electron microscopy; Ultraviolet visible spectroscopy; X ray diffraction; Anti-bacterial activity; Experimental parameters; Gallic acids; Minimum inhibitory concentration; Nanobiomedicine; Narrow size distributions; Spherical morphologies; UV-vis spectroscopy; Gold nanoparticles; gallic acid; gold; gold nanoparticle; aqueous solution; article; bactericidal activity; broth dilution; controlled study; drug potentiation; drug synthesis; light scattering; minimum inhibitory concentration; morphology; nonhuman; particle size; pH; priority journal; Streptococcus mutans; transmission electron microscopy; ultraviolet spectroscopy; X ray diffraction
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