Isobolographic analysis of the analgesic combination sistemic ketorolac and local tramadol in the formalin test in mice [Análisis isobolográfico de la combinación analgésica ketorolaco sistémico y tramadol local en el modelo de la formalina en ratones]
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abstract
Balanced analgesia refers to the combination of two or more agents and/or routes of administration. The objective of this study was to evaluate the analgesic interaction of systemic ketorolac (SK) and local tramadol (LT) using the formalin test in mice. SK was 20 minutes before the subcutaneous injection of formalin (3%25) in doses of 0.18, 0.5, 1.8, 3.2 mg/kg. LT was simultaneously administered with formalin in doses of 50, 100, 250, and 400 μg/paw. The antinociceptive effect of the combination SK-LT was evaluated by using a fixed-ratio (1:805) sequential dilutions scheme. Isobolographic analysis demonstrated that the experimental ED50 is significantly smaller that the theoretical (p<0.05). The results suggest that proposed therapeutic strategy may be a promissory tool for the relief of moderate to severe pain.
