A defect in immunoregulatory synovial fluid T cells in Behcet's syndrome Article

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Overview

abstract

• Synovial fluid mononuclear cells from 5 patients with active Behcet%27s syndrome who were receiving no treatment were observed to have: decreased proportions of CD4 and CD8 cells, decreased proliferative responses of T cells in AMLR, poor capacity of non-T cells to stimulate in AMLR, decreased production of IL-2 upon PHA stimulation as compared both to their own peripheral blood mononuclear cells and to synovial fluid and peripheral blood mononuclear cells from 6 patients with RA and 6 patients with synovial effusions due to noninflammatory conditions. These findings provide further evidence of an immunoregulatory disturbance in Behcet%27s syndrome and indicate that synovial fluid, may be an important site where this derangement occurs in the active stage of the disease. © 1989 Springer-Verlag.
• Synovial fluid mononuclear cells from 5 patients with active Behcet%27s syndrome who were receiving no treatment were observed to have: decreased proportions of CD4%2b and CD8%2b cells, decreased proliferative responses of T cells in AMLR, poor capacity of non-T cells to stimulate in AMLR, decreased production of IL-2 upon PHA stimulation as compared both to their own peripheral blood mononuclear cells and to synovial fluid and peripheral blood mononuclear cells from 6 patients with RA and 6 patients with synovial effusions due to noninflammatory conditions. These findings provide further evidence of an immunoregulatory disturbance in Behcet%27s syndrome and indicate that synovial fluid, may be an important site where this derangement occurs in the active stage of the disease. © 1989 Springer-Verlag.
• Synovial fluid mononuclear cells from 5 patients with active Behcet's syndrome who were receiving no treatment were observed to have: decreased proportions of CD4%2b and CD8%2b cells, decreased proliferative responses of T cells in AMLR, poor capacity of non-T cells to stimulate in AMLR, decreased production of IL-2 upon PHA stimulation as compared both to their own peripheral blood mononuclear cells and to synovial fluid and peripheral blood mononuclear cells from 6 patients with RA and 6 patients with synovial effusions due to noninflammatory conditions. These findings provide further evidence of an immunoregulatory disturbance in Behcet's syndrome and indicate that synovial fluid, may be an important site where this derangement occurs in the active stage of the disease. © 1989 Springer-Verlag.

authors

• Abud Mendoza Carlos
• Alarcón-Segovia D.
• Alcocer-Varela J.
• Laffon A.

publication date

• 1989-01-01

published in

• Clinical Rheumatology  Journal

Research

keywords

• Behcet's Syndrome; Immunoregulation; Synovial Fluid T Cells adult; article; behcet disease; clinical article; female; human; immunoregulation; male; synovial fluid; t lymphocyte; Adult; Behcet Syndrome; Female; Human; Male; Middle Age; Support, Non-U.S. Gov't; Synovial Fluid; T-Lymphocytes

Identity

Digital Object Identifier (DOI)

• 10.1007/BF02031074

PubMed ID

• 2787226

Additional Document Info

start page

• 80

end page

• 86

volume

• 8

issue

• 1