Population pharmacokinetics of carbamazepine in epileptic children [Farmacocinética poblacional de carbamazepina en niños epilépticos] Article uri icon

abstract

  • The aim of the present study was to evaluate the factors affecting carbamazepine (CBZ) clearance (CL) values for epileptic pediatric patients using serum concentration gathered during their routine clinical care. 124 CBZ serum concentrations data collected from 79 children were studied. Data were analyzed according to a one compartment model with first-order absorption and elimination, using the NONMEM program. The influence of total body weight, age, CBZ daily dose (DD), gender, body surface area (BSA) and comedication with valproate or phenytoin (PHT) were investigated. The final model was: CL/F (L/h) = (0.731 * BSA 0.00197 * DD) * (1 0.51* PHT). The validation of the model has supported its acceptability and it could be used for clinical purposes to establish individualized dosage regimens of CBZ.
  • The aim of the present study was to evaluate the factors affecting carbamazepine (CBZ) clearance (CL) values for epileptic pediatric patients using serum concentration gathered during their routine clinical care. 124 CBZ serum concentrations data collected from 79 children were studied. Data were analyzed according to a one compartment model with first-order absorption and elimination, using the NONMEM program. The influence of total body weight, age, CBZ daily dose (DD), gender, body surface area (BSA) and comedication with valproate or phenytoin (PHT) were investigated. The final model was: CL/F (L/h) = (0.731 * BSA %2b 0.00197 * DD) * (1%2b0.51* PHT). The validation of the model has supported its acceptability and it could be used for clinical purposes to establish individualized dosage regimens of CBZ.

publication date

  • 2009-01-01