abstract

• Nowadays, research on human diseases has focused on the study of molecular characteristics to identify markers related to the onset of the pathophysiological process and its complications. Exosomes are nanovesicles constituted by a lipid bilayer with a size between 40 and 70nm that have been considered an important source of biological information, carrying to distant targets different biomolecules such as proteins, lipids, and nucleic acids, including RNA. A wide variety of RNA types can be contained within exosomes, ranging from messenger RNAs to noncoding RNAs. In this sense, exosomes have emerged as a promising strategy because they are circulating vesicles widely distributed in different body fluids, such as blood and urine. Several studies have proposed exosomal RNAs as promising tools in the diagnosis, prognosis, and treatment of renal disease; current evidence suggests that exosomes may contribute to the development and, at the same time, regulate tissue repair. Therefore, exosomal RNAs could be a target for pharmacological treatment and potentially be used therapeutically in acute and chronic kidney damage. © 2024 Elsevier Inc. All rights are reserved including those for text and data mining AI training and similar technologies.

authors

• Cortés-García J.D.
• González-Palomo A.K.
• Jiménez-Avalos J.A.
• Turiján-Espinoza E.

publication date

• 2024-01-01

published in

• Exosomal RNA: Role in Human Diseases and Therapy  Book

keywords

• Chronic kidney disease; Diabetic kidney disease; Exosomes; Kidney disease; Lupus nephritis; Noncoding RNA; Renal cancer; RNA

Digital Object Identifier (DOI)

• 10.1016/B978-0-443-14008-2.00005-X

PubMed ID

start page

• 249

end page

• 270

volume

issue