Basic virological aspects of SARS-CoV-2
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Coronaviruses (CoVs) belong to a group of positive-sense single-stranded RNA viruses that have the largest genome known for a virus and use RNA as its genetic material. These viruses can infect a wide variety of animals, causing very different diseases that include common cold (humans), peritonitis (cats), hepatitis (mouse), and life-threatening pneumonia (humans). In fact, before the year 2002, most of the CoV literature focused on viruses of veterinarian interest. This changed in 2002 and 2012 with the appearance of two novel human CoVs that cause Severe Acute Respiratory Syndromes, SARS-CoV and MERS-CoV, respectively. The localized epidemics caused by these two viruses served as warning events on how zoonotic transmission of CoVs between bats (or camels) and humans could result in the formation of new viruses. Unfortunately, the research on these viruses mostly caught only the attention of the groups that either previously worked with CoVs of veterinarian interest or lived in the regions affected by SARS-CoV and MERS-CoV. © 2022 Elsevier Inc. All rights reserved.
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coronaviruses; infectious cycle; positive-sense single-stranded RNA viruses; SARS-CoV-2; virology
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