abstract

• It is important and valuable to study the generation of reactive oxygen species when applying external radiation with electrons which energy is 5 keV to physical system: composite system and intracellular water. In order to do this, computer simulations of Monte Carlo (TOPAS-nBio code) were used. For the study of generation of reactive species, this work focus was exclusively on the interaction between secondary radiation from the composite system and intracellular water. This secondary radiation originates from the platinum atom and oxygens (from the composite system) the influence being greater relative to platinum; which mainly consists of electrons called Auger. In this work, only the influence of these ionizing electrons in intracellular water is considered, leading to the generation of reactive oxygen species. Furthermore, the interaction between the nanoparticle surface and cisplatin was not taken into account.

publication date

• 2021-01-01

published in

• International Journal of Scientific %26 Engineering Research  Journal

keywords

• Cisplatin, compound system, external radiation, intracellular water, nanoparticles, reactive oxygen species, TOPAS-nBio code

Digital Object Identifier (DOI)

PubMed ID

start page

• 42-49

end page

volume

• 12

issue

• 5