Right Ventricular Systolic Pressure in Coronavirus Disease 2019 (COVID-19) Patients
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Rationale:Right ventricular dysfunction is associated with increased mortality in hospitalizedCOVID-19 patients. Early mitigation of right ventricular dysfunction may have an impact on patients’outcomes and recovery. The purpose of this study was to describe the association of rightventricular systolic pressure (RVSP) and mortality in different age groups. Methods: Retrospectivestudy of patients admitted to our hospital with COVID-19 from March 2020 to February 2022.Patients with echocardiographic data were identified and assessed. The patients were divided ingroups by age: group 1 (17-39 years), group 2 (40-59 years), group 3 (60-64 years), group 4 (65-74years), group 5 (75-84 years), and group 6 (85 years or older). Primary outcome was mortality.Descriptive statistics, Mann-Whitney-U methods and Kruskal-Wallace were utilized to ascertainstatistical significance. Results: 806 patients with available information of echocardiographic datawere included. The median age was 56 years [45-66]. A total of 415 (55.8%25) patients were male.The median RVSP was 29.7mmHg [21.1-36.9]. A higher RVSP was observed in patients that died(31.53 [23.5-42.6] vs 29.33 [20.79-36.34] mmHg p=0.003). There was a significant difference inmortality when comparing age groups by RVSP. For group 1 median RVSP was 27.7 mmHg [20.4-34.4], group 2 was 27.8 mmHg [20.5-35.8], group 3 was 34.0 mmHg [26.03-39.8], group 4 was30.0 mmHg [21.3-40.2], group 5 was 31.6 mmHg [22.9-43.3], and group 6 was 32.0mmHg [22.6-46.3] p=0.001. A Post Hoc analysis revealed a significantly different RVSP between group 1 and 3(p=0.001), group 1 and 5 (p=0.049), group 2 and 3 (p<0.001), and between group 2 and 5(p=0.028). The adjusted odds ratio (ORa) by age >65 and gender for mortality in patients withRSVP > 39.99 mmHg was 1.85 (95%25CI 1.22-2.80, p=0.005). Conclusions:COVID-19 patients olderthan 65 years, presenting with RVSP >39.99 have 1.85 times higher chance of death whencompared to other groups
