Hyperoxemia as an Additional Source of Systemic Injury in Coronavirus Disease 2019 (COVID-19) Patients
Conference Paper
Overview
Research
Identity
Additional Document Info
View All
Overview
abstract
Rationale: Acute respiratory distress syndrome (ARDS) is characterized by a decreased oxygenpressure in the blood and tissues with patients requiring supplemental oxygen to meet metabolicdemands. However, hyperoxemia and the resultant tissue hyperoxia may worsen systemic organinjury through the development of reactive oxygen species (ROS). The aim of this study was toevaluate the association between hyperoxemia, inflammatory markers, Ichikado CT score, andmortality of COVID-19 critically ill patients. Methods: Retrospective cohort study of COVID-19patients admitted to our hospital from March 2020 to February 2022. Patients who receivedsupplemental oxygen (FIO2 ≥60%25) were divided into two equal and randomly selected groups:group 1 (G1) were patients with hyperoxemia (defined as PaO2 ≥100mmHg) and group 2 (G2)were patients with no hyperoxemia (PaO2 <100mmHg). Primary outcomes included mortality andlength of hospital stay (LOS). Secondary assessments were Ichikado computed tomography (CT)score and inflammatory markers. Descriptive statistics, chi-square, and Mann-Whitney-U tests wereutilized to determine statistical significance. Results: 54 patients were included, 37(68.5%25) weremale with mean age 59.63 (±14.2) years, median body mass index (BMI) 29.45 [25.6-33.8] Kg/m2.26 (48.1%25) patients survived hospital discharge. There was no significant difference in gender, age,or BMI between the groups. When comparing the Ichikado CT scores between groups, nodifference was found. No significant difference was found when assessing Interleukin 6 (IL-6)(125.6[26.5-733.2] vs 68 [15.1-384.5] p=0.317), Interleukin 10 (IL-10) (56.3[35.6-172.47] vs (57[24-193.9] p=0.768), Ferritin (1443.6[515.7-1600] vs 893[402.1-1500] p=0.281, C Reactive Protein(CRP) (121[102.7 -177.1] vs (104.85[55.5-192.4] p=0.618) and D-dimer (5.66[SD=3.9] vs 4.04[SD=3.] p=0.1). Additionally, there was no statistically significant difference when evaluatingmortality between the 2 groups (12[44.4%25] vs 16 [59.3%25] p=0.276). Conclusion: This study showedthat hyperoxemia was not associated with increased mortality, LOS, inflammatory markers, orseverity scores, compared to prior reports.
