Protective effect of aqueous extract of calea urticifolia in a mouse model of diabetic neuropathy
Article
Overview
Research
Identity
Additional Document Info
View All
Overview
abstract
Diabetes mellitus is a disease that causes microvascular alterations and degeneration in sensory nerves; The symptoms result in the presence of pain and functional impairments regulated by the peripheral nervous system. These conditions are referred to as diabetic peripheral neuropathies. One medicinal plant for the prevention and treatment of diabetes-associated neuropathic changes is Calea urticifolia (CuAqE), which is utilized by the Xi’uy ethnic group in México. In this study, we aimed to evaluate the therapeutic potential of CuAqE using a dose of 11 mg/kg in type-I diabetic neuropathy model induced by low doses of streptozotocin to 50mg/kg in C57BL/6 mice, characterized by fasting blood glucose >200 mg/dL on C57BL/6 mice. The objective of this study was to evaluation of CuAqE using non-stimulus evoked nociception methods, including the Mouse Grimace Scale and Body Condition Score as well as stimulus-evoked pain-like behaviors, specifically the mechanical paw withdrawal threshold. CuAqE administration resulted in a decrease in hyperglycemia levels; however, it failed to maintain physiological glucose levels and produced pain attenuation without affecting constipation behavior (p<0.005). In diabetic mice, thresholds for mechanical hypersensitivity were reduced, and CuAqE treatment did not show a significant change (p<0.001). These findings reveal protective action of CuAqE against pain hypersensitivity in mouse models of type I diabetes and provide insights for the development of novel approaches to manage diabetes using traditional medicine.
