abstract

• OBJECTIVE: To evaluate the morphological changes of cardiomyocytes exposed to different sodium fluoride (NaF) concentrations, as well as to evaluate the behavior of the mitochondria. METHODS: Rat H9c2 cardiomyocytes were exposed to NaF at concentrations of 0.5 to 5 mmol/L. The morphology and number of mitochondria in these cells were monitored, and the calcium ion (Ca2 ) concentration was determined. RESULTS: Morphological changes were evident in the cells treated with different NaF concentrations, and both the number of mitochondria and the Ca2 concentration decreased in a dose-dependent manner. CONCLUSION: Sodium fluoride induced morphological damage in cardiomyocytes, decreases the Ca2 concentration and mitochondrial number.

authors

• Escobar García Diana María
• Pozos Guillén Amaury de Jesús
• Rodríguez y Domínguez Kessler Margarita
• Salgado Delgado Roberto Carlos

publication date

• 2023-01-01

published in

• Puerto Rico health sciences journal  Journal

keywords

• Ca2 concentration, Cardiomyocytes, Fluoride, Mitochondria, Morphological change

Digital Object Identifier (DOI)

PubMed ID

• 37352535

start page

• 132

end page

• 138

volume

• 42

issue

• 2