Local antinociceptive effect of \snow mountain garlic\ in an experimental formalin model

Medicinal plants are currently employed for curative purposes in developing and developed countries. One example is garlic (Snow mountain garlic, also called \Himalayan garlic\), used for its multiple therapeutic properties since ancient times. The local Himalayan population generally consumes it as a remedy for rheumatoid arthritis. This study aimed to evaluate the antinociceptive and anti-inflammatory effect of a \Snow mountain garlic\ extract in a formalin test. Nociception was measured (number of paw flinches/shakes during one h for 5 min periods), under the administration of 50 mu L with formalin 5%25, saline solution 0.9%25, Snow mountain essential oil 500 mu g/kg, diclofenac 250 mu g/kg, naproxen 400 mu g/kg, and tramadol 500 mu g/kg in independent groups. Snow mountain garlic extract has an antinociceptive effect on Phase 2 of the formalin test, which is associated with the inflammatory component of pain, and its behaviour is comparable to that of traditional NSAIDs used in the clinic.

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