abstract

• Over 200 different SARS-CoV-2 lineages have been observed in Mexico by November 2021. To investigate lineage replacement dynamics, we applied a phylodynamic approach and explored the evolutionary trajectories of five dominant lineages that circulated during the first year of local transmission. For most lineages, peaks in sampling frequencies coincided with different epidemiological waves of infection in Mexico. Lineages B.1.1.222 and B.1.1.519 exhibited similar dynamics, constituting clades that likely originated in Mexico and persisted for >12 months. Lineages B.1.1.7, P.1 and B.1.617.2 also displayed similar dynamics, characterized by multiple introduction events leading to a few successful extended local transmission chains that persisted for several months. For the largest B.1.617.2 clades, we further explored viral lineage movements across Mexico. Many clades were located within the south region of the country, suggesting that this area played a key role in the spread of SARS-CoV-2 in Mexico. © 2023, eLife Sciences Publications Ltd. All rights reserved.

authors

• Arias C.F.
• Comas García Andreu
• López S.
• Taboada B.

publication date

• 2023-01-01

published in

• eLife  Journal

keywords

Digital Object Identifier (DOI)

• 10.7554/eLife.82069

PubMed ID

• 37498057

start page

end page

volume

• 12

issue